What Zofran Zydis wafers look like. Zofran Zydis is a special type of tablet called a 'wafer'. Zofran Zydis wafers are white, round wafers, with no markings on either side. They come in a foil blister pack of 4 or 10 wafers, which are contained in a box. There is a 4 mg strength and an 8 mg strength. Ingredients. Zofran Zydis wafers contain either 4 mg or 8 mg of the active ingredient. Dosing and Route • Adults: 4 mg oral dissolve tablet (ODT) or slow IVP (over no less than 30 sec.) May repeat X 1 in 10 minutes to a total of 8 mg. ANTIEMETICS AND ANTINAUSEANTS: Shortage reports. Brand name Packaging Size Status Date Created Ondansetron, marketed under the brand name Zofran, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. It is also useful in gastroenteritis. Zofran (ondansetron) blocks the actions of chemicals in the body that can trigger nausea and vomiting. Zofran is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment. Ondansetron, commonly known as Zofran, is a drug created to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy and surgery. This may stem from the fact that Zofran isn’t created specifically for nausea and vomiting. It’s main function is to treat those with cancer, as surgery, chemotherapy, and radiation can cause nausea. However, doctors are still legally allowed to prescribe the medication how they wish. Zofran is used to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer (chemotherapy or radiation). Zofran is not for preventing nausea or vomiting that is caused by factors other than cancer treatment or surgery. Zofran Lawsuit Take Zofran for Morning Sickness? You may be entitled to compensation Overview Side Effects Dosage Interactions Professional More. The drug Zofran is quite commonly known by its chemical name, which is ondansetron. This substance was invented in the early 1980s in England by an affiliate of its maker in the US, which is GlaxoSmithKline (GSK). Zofran How it Works: Copious amounts of serotonin flood the system when something like chemotherapy or radiation upsets stomach cells. Serotonin triggers the nerves of the gut to empty the stomach.